Mitochondrial dynamics mitochondrial fission and fusion in human diseases

Mitochondrial fission and fusion in human diseases.

mitochondrial dynamics mitochondrial fission and fusion in human diseases

POD: Mitochondrial Fusion & Fission

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Hsiuchen Chen, David C. Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial dysfunction often have a neurodegenerative component. Recent discoveries have highlighted that neurons are reliant particularly on the dynamic properties of mitochondria. Mitochondria are dynamic organelles by several criteria. They engage in repeated cycles of fusion and fission, which serve to intermix the lipids and contents of a population of mitochondria. In addition, mitochondria are actively recruited to subcellular sites, such as the axonal and dendritic processes of neurons.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Mitochondria are essential components of eukaryotic cells, carrying out critical physiological processes that include energy production and calcium buffering. Consequently, mitochondrial dysfunction is associated with a range of human diseases. Fundamental to their function is the ability to transition through fission and fusion states, which is regulated by several GTPases.

Skip to search form Skip to main content. Mitochondrial dynamics--mitochondrial fission and fusion in human diseases. Alterations in mitochondrial dynamics underlie various human diseases, including cancer and neurologic and cardiovascular diseases. Defining the alterations may identify potential therapeutic targets. View PDF. Save to Library.

Posted in Clinical Review Article on 1st Apr Motor features such as resting tremor, bradykinesia, rigidity and postural instability, can be attributed to the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Together, these motor and non-motor features cause significant disability and drastically reduce quality of life in the afflicted patients. It has been estimated that up to 10 million people worldwide are affected by PD and approximately , people in the UK are living with this disease. PD also causes an enormous economic burden. To achieve this goal, it is critical to understand the aetiology and underlying mechanisms of neuronal dysfunction and degeneration in PD. The cause s of the majority of PD cases remains unknown.

Mitochondrial fission

As the lifespan of humans increases, AD is becoming more prevalent disease. Mitochondria are essential organelles involved in oxidative phosphorylation, ATP production, metabolism of some neurotransmitters, amino acids and nucleotides, calcium homeostasis, reactive oxygen species management and programmed cell death [ 5 7 ]. Mitochondria are highly dynamic organelles that are reshaped by opposing processes of fusion and fission.




5 thoughts on “Mitochondrial dynamics mitochondrial fission and fusion in human diseases

  1. Although mitochondria are commonly depicted as singular oval-shaped structures, it has been known for at least a century that they form a highly dynamic network within most cells where they constantly undergo fission and fusion.

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